TABLE 3.

Aminoglycoside susceptibilities of ΔmexXY derivatives of clinical P. aeruginosa strains

Strain	MIC (μg/ml)a
	AMI	GEN	KAN	LIV	NEO	PAR	SPC	STR	TOB	ERY	TET	NOR
K767	2	4	128	16	64	512	1,024	16	1	512	16	0.5
K1525	1	2	64	4	16	32	128	2	1	128	16	0.5
ΔMICb	2	2	2	4	4	16	8	8	1	4	1	1
K2152	8	8	128	64	128	512	2,048	32	4	512	32	1
K2164	4	4	64	8	32	32	128	4	2	128	32	1
ΔMIC	2	2	2	8	4	16	16	8	2	4	1	1
K2153	16	16	128	64	128	512	2,048	64	4	512	32	1
K2165	2	4	64	16	16	16	128	8	4	128	128	1
ΔMIC	8	4	2	4	8	32	16	8	1	4	0.25	1
K2155	1	4	16	16	8	32	512	16	1	256	32	4
K2166	0.5	2	16	4	8	8	128	4	1	32	32	4
ΔMIC	2	2	1	4	1	4	4	4	1	8	1	1
K2156	32	32	512	128	128	512	2,048	256	8	512	16	8
K2167	1	4	64	4	16	32	64	4	1	256	16	4
ΔMIC	32	8	8	32	8	16	32	64	8	2	1	2
K2160	64	32	512	512	128	512	512	128	16	256	16	1
K2168	16	8	256	32	64	64	64	16	8	32	16	1
ΔMIC	4	4	2	16	2	8	8	8	2	8	1	1
K2161	64	64	1,024	256	512	>2,048	256	64	16	512	16	0.5
K2169	8	8	256	32	64	64	64	8	8	256	16	0.5
ΔMIC	8	8	4	8	8	32	4	8	2	2	1	1
K2162	256	256	2,048	2,048	1,024	>2,048	2,048	256	64	512	32	2
K2170	32	16	512	64	128	256	128	16	16	512	32	2
ΔMIC	8	16	4	32	8	8	16	16	4	1	1	1
K258	32	16	512	128	256	2,048	2,048	64	16	1,024	64	1
K2171	8	4	256	32	64	64	512	16	8	1,024	64	1
ΔMIC	4	4	2	4	4	32	4	4	2	1	1	1
K2163	16	8	128	64	32	256	1,024	32	8	256	32	1
K2172	8	2	64	16	16	32	256	8	4	128	32	1
ΔMIC	2	4	2	4	2	8	4	4	2	2	1	1

^aAbbreviations: AMI, amikacin; GEN, gentamicin; KAN, kanamycin; LIV, lividomycin; NEO, neomycin; PAR, paromomycin; SPC, spectinomycin; STR, streptomycin; TOB, tobramycin; ERY, erythromycin; TET, tetracycline; NOR, norfloxacin.

^bΔMIC, ratio of MIC for the parent strain and the MIC for the corresponding ΔmexXY derivative.