TABLE 2.
Agar dilution MICs for 261 pneumococcal strains classified by erythromycin A susceptibility
| Drug and strain category (n)a | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| Penicillin G | |||
| Erythromycin S (141) | 0.016-4.0 | 0.125 | 2.0 |
| Erythromycin R (120) | 0.016-16.0 | 1.0 | 4.0 |
| XRP 2868 | |||
| Erythromycin S | 0.06-0.25 | 0.125 | 0.25 |
| Erythromycin R | 0.06-1.0 | 0.25 | 0.5 |
| RPR 132552 | |||
| Erythromycin S | ≤0.5-16.0 | 4.0 | 8.0 |
| Erythromycin R | ≤0.5->64.0 | 4.0 | 32.0 |
| RPR 202868 | |||
| Erythromycin S | ≤0.5-32.0 | 4.0 | 8.0 |
| Erythromycin R | 2.0->64.0 | 16.0 | 64.0 |
| Pristinamycin | |||
| Erythromycin S | 0.125-0.5 | 0.25 | 0.25 |
| Erythromycin R | 0.125-1.0 | 0.25 | 0.5 |
| Quinupristin/dalfopristin | |||
| Erythromycin S | ≤0.06-1.0 | 0.5 | 0.5 |
| Erythromycin R | 0.25-1.0 | 0.5 | 1.0 |
| Quinupristin | |||
| Erythromycin S | ≤0.5-8.0 | 2.0 | 4.0 |
| Erythromycin R | 1.0->64.0 | 8.0 | 64.0 |
| Dalfopristin | |||
| Erythromycin S | 8.0->64.0 | 64.0 | >64.0 |
| Erythromycin R | 8.0->64.0 | >64.0 | >64.0 |
| Erythromycin A | |||
| Erythromycin S | 0.016-0.25 | 0.06 | 0.125 |
| Erythromycin R | 1.0->64.0 | >64.0 | >64.0 |
| Azithromycin | |||
| Erythromycin S | 0.03-0.25 | 0.125 | 0.125 |
| Erythromycin R | 1.0->64.0 | >64.0 | >64.0 |
| Clarithromycin | |||
| Erythromycin S | ≤0.008-0.125 | 0.03 | 0.06 |
| Erythromycin R | 0.25->64.0 | >64.0 | >64.0 |
| Clindamycin | |||
| Erythromycin S | ≤0.008-0.125 | 0.06 | 0.06 |
| Erythromycin R | 0.016->64.0 | 1.0 | >64.0 |
a
S, susceptible; R, resistant.