TABLE 3.
PA SMEs of PGE-9509924, levofloxacin, and ciprofloxacin
| Strain | PA SMEa (h) at indicated multiple of the MIC
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| PGE-9509924
|
Levofloxacin
|
Ciprofloxacin
|
|||||||
| 0.1 | 0.2 | 0.3 | 0.1 | 0.2 | 0.3 | 0.1 | 0.2 | 0.3 | |
| S. pneumoniae ATCC 6306 | 11.4 (4.7-18.1) | 12.4 (6.6-18.1) | 15.9 (13.7-18.1) | 3.0 (2.9-3.0) | 4.4 (3.3-5.4) | 19.6 (19.2-20) | 1.9 (1.7-2.1) | 4.0 (4.0-4.0) | 7.3 (7.1-7.5) |
| S. pneumoniae R 2151 | 8.7 (8.1-9.3) | 11.5 (11-12) | 13.2 (12.14.4) | 3.2 (3.0-3.3) | 7.8 (5.4-10.1) | 13.2 (10.9-15.4) | 1.3 (1.0-1.5) | 3.4 (2.4-4.4) | 7.0 (4.6-9.4) |
| S. aureus ATCC 29213 | 4.5 (4.1-4.9) | 14.3 (11.2-17.4) | 18.3 (18.1-18.5) | 2.8 (2.4-3.1) | 5.8 (5.6-5.9) | 14.4 (8.8-19.9) | 1.0 (0.6-1.3) | 2.3 (1.4-3.1) | 5.3 (2.0-8.5) |
| S. aureus Col. 1841 | 2.8 (2.4-3.1) | 5.0 (4.0-5.9) | 11.3 (7.1-15.5) | 1.8 (1.4-2.2) | 2.9 (2.4-3.4) | 4.7 (3.0-6.3) | 2.6 (1.1-4.0) | 6.2 (1.1-11.2) | 10.3 (1.8-18.8) |
| S. aureus CCUG 35601 | 2.0 (1.4-2.5) | 6.0 (5.1-6.9) | 17.0 (16.6-17.3) | 2.0 (1.3-2.6) | 17.6 (17.6-17.6) | 17.6 (17.6-17.6) | 3.6 (3.0-4.2) | 18.5 (18.1-18.9) | 18.5 (18.1-18.4) |
| E. coli ATCC 25922 | 2.8 (2.6-3.0) | 7.7 (4.3-11.1) | 12.2 (4.9-19.4) | 3.3 (2.8-3.7) | 4.2 (3.4-4.9) | 14.2 (7.3-21.1) | 3.1 (2.5-3.6) | 6.2 (4.4-7.9) | 20.2 (19.4-21) |
| K. pneumoniae ATCC 13883 | 1.9 (1.9-1.9) | 4.4 (4.4-4.4) | 12.8 (9.4-16.1) | 1.5 (1.2-1.8) | 4.0 (3.2-4.8) | 9.6 (6.9-12.2) | 1.1 (0.6-1.5) | 2.9 (2.9-2.9) | 6.7 (6.5-6.9) |
| P. aeruginosa ATCC 27853 | 1.1 (0.6-1.6) | 7.5 (7.5-7.5) | 14.6 (14.0-15.1) | 1.1 (0.8-1.4) | 2.8 (2.2-3.3) | 6.4 (5.6-7.1) | 2.5 (2.0-3.0) | 10.5 (9.4-11.5) | 14.0 (13.6-14.4) |
a
Values are means of two experiments, with ranges in parentheses.