TABLE 4.

SMEs of PGE-9509924, levofloxacin, and ciprofloxacin

Strain	SMEa (h) at indicated multiple of the MIC
	PGE-9509924			Levofloxacin			Ciprofloxacin
	0.1	0.2	0.3	0.1	0.2	0.3	0.1	0.2	0.3
S. pneumoniae ATCC 6306	1.1 (0.6-1.6)	6.5 (2.4-10.5)	12.0 (5.3-18.6)	0.4 (0.3-0.4)	2.7 (2.3-3.1)	8.3 (7.5-9.0)	0.5 (0.5-0.5)	1.9 (1.8-2.0)	5.6 (4.6-6.5)
S. pneumoniae R2151	2.2 (2.0-2.4)	4.8 (3.0-6.6)	8.7 (3.8-13.6)	1.3 (1.0-1.6)	5.6 (3.1-8.0)	10.8 (5.9-15.6)	0.8 (0.3-1.3)	3.3 (1.9-4.9)	8.9 (3.8-14.0)
S. aureus ATCC 29213	1.3 (0.6-1.9)	7.4 (2.8-12.0)	15.8 (13.5-18.0)	0.3 (2.4-3.1)	1.3 (5.6-5.9)	9.9 (8.8-19.9)	0 (0-0)	0.5 (0.3-0.6)	1.0 (0.8-1.1)
S. aureus Col. 184	0.8 (0.6-0.9)	1.9 (1.3-2.5)	3.6 (2.8-4.4)	0.2 (0-0.3)	1.0 (0.9-1.1)	1.4 (1.1-1.6)	0 (0-0)	0.1 (0-0.2)	0.3 (0-0.5)
S. aureus CCUG 35601	0.9 (1.4-2.5)	2.0 (5.1-6.9)	8.9 (16.6-17.3)	0.6 (1.3-2.6)	10.5 (17.6-17.6)	18.7 (17.6-17.6)	0.7 (3.0-4.2)	9.7 (18.1-18.9)	18.3 (18.1-18.4)
E. coli ATCC 25922	0 (0-0)	0.2 (0-0.3)	1.0 (0.5-1.4)	0.1 (0-0.1)	0.4 (0.3-0.4)	1.2 (0.8-1.6)	0.3 (0.3-0.3)	1.2 (0.8-1.6)	13 (5-21)
K. pneumoniae ATCC 13883	0.4 (0.3-0.4)	2.4 (1.9-2.9)	13.4 (10.6-16.1)	0.2 (0-0.3)	2.0 (1.3-2.6)	9.4 (8.8-10.0)	0.5 (0.4-0.6)	1.9 (1.9-1.9)	6.4 (6.3-6.4)
P. aeruginosa ATCC 27853	0.9 (0.4-1.3)	9.9 (6.4-13.3)	14.4 (13.3-15.4)	0.6 (0.3-0.9)	2.3 (2.0-2.5)	4.0 (2.9-5.0)	1.0 (0-1.9)	8.4 (4.0-12.8)	13.4 (12.8-14.0)

^aValues are means of two experiments, with ranges in parentheses.