TABLE 2.
Effect of oral administration of FB1 on bacterial colonization of piglet intestines by E. coli strain 28CNalr
| Expt and treatment | Bacterial colonization of
sections (log10 [CFU/g])
ofc:
|
||
|---|---|---|---|
| Ileum | Cecum | Colon | |
| Expt 1a | |||
| Control | 1.66 ± 0.14b | 2.99 ± 0.32 | 3.32 ± 0.77 |
| FB1 extract | 4.26 ± 0.42 | 5.85 ± 0.40 | 6.03 ± 0.37 |
| Expt 2 | |||
| Control | 2.74 ± 0.34 | 3.72 ± 0.42 | 3.73 ± 0.38 |
| Purified FB1 | 3.67 ± 0.64 | 5.07 ± 0.58 | 5.62 ± 0.63 |
a
Pigs were dosed for 7 days with 0.5 mg of FB1/kg of body weight, administered as a crude extract (experiment 1) or as a purified toxin (experiment 2).
b
Results are expressed as geometric mean bacterial counts ± standard errors of the means for a group of four to five pigs.
c
Two-way ANOVA did not reveal any effect of the experiment but indicated a significant effect of FB1 treatment on the bacterial count in the different parts of the intestine. For the results for the ileum, cecum, and colon, the effects of the FB1 treatment in both experiments were significant at a P value of 0.0009, 0.0003, and 0.0001, respectively.