FIG. 2.
FISH on dental plaque samples from human subgingival sites of moderate chronic periodontitis (A to E) and from healthy sites (F). (A.1 to A.3) Staining with YO-PRO-1 (green) general stain (A.1) and TM7-905-Cy5 (blue) (A.2) and colocalization of these two stains (A.3). Asterisks, two segments of the TM7 filament that are not labeled by the probe. In all other panels, YO-PRO-1 and probe signals are merged as in panel A.3. (B and C) TM7-905 probe and YO-PRO-1-labeled cells (blue-green); (D to F) TM7-905 probe-labeled cells (solid arrowhead, dark blue) plus IO25-136 probe-labeled cells (open arrowhead, light blue) and cells labeled with YO-PRO-1 alone (green). Scale bar = 5 μm in all panels.