Figure 3.

Murine APL. (a and b) Bone marrow isolates. (a) Control FVB/N. (b) Leukemia (mouse 1333, line 556). (c and d) Cytospins of 7-day methylcellulose cultures from passage 1 of leukemia 877 (line 553) cultured without (c) or with (d) 1 μM ATRA. (e and f) Bone marrow isolates from third passage of leukemia 877. On day 11 after transplantation, pellets containing placebo (e) or 5 mg ATRA (f) were implanted. Samples were prepared on day 16 after transplantation. Cells were stained with Wright’s Giemsa with Azure B. (×250.)