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Contractions to increasing concentrations of acetylcholine (left) or calcium ionophore A23187 (right) in rings of SHR or WKY aorta with (+EC) or without endothelium (−EC), in the absence or presence of either indomethacin (indo, 10−5 M) or Tiron (10−2 M) plus DETCA (10−4 M). Data are expressed as absolute changes in force (Newtons) and shown as means±s.e.m.; n=5.
