Table 1.
The occurrence of contractions, intracellular calcium and ROS elevations in endothelial cells of rat aortic rings (in the presence of 10−4 M L-NAME and 10−7 M S18886)
| Contraction | Endothelial calcium | Endothelial ROS | |
|---|---|---|---|
| WKY | |||
| Ach | No | ↑ Not inhibited by indomethacin, Tiron+DETCA | No Change |
| A23187 | Yes; inhibited by indomethacin, Tiron+DETCA | ↑ Not inhibited by indomethacin, Tiron+DETCA | ↑ Inhibited by indomethacin, Tiron+DETCA |
| SHR | |||
| Ach | Yes; inhibited by indomethacin, Tiron+DETCA | ↑ Not inhibited by indomethacin, Tiron+DETCA (>WKY) | ↑ Inhibited by indomethacin, Tiron+DETCA (>WKY) |
| A23187 | Yes; inhibited by indomethacin, Tiron+DETCA | ↑ Not inhibited by indomethacin, Tiron+DETCA (=WKY) | ↑ Inhibited by indomethacin, Tiron+DETCA (=WKY) |
Abbreviations: DETCA, diethyldithiocarbamate; L-NAME, Nω-nitro-L-orginine methyl ester; ROS, reactive oxygen species; SHR, spontaneously hypertensive rats; WKY, Wistar–Kyoto rats.