Table 4.

V_max, K_m and CL_int for the disappearance of terazosin with or without DA-8159

Parameter	Without DA-8159	With DA-8159
Vmax (nmol min−1 mg protein−1)	0.311±0.0303	0.268±0.0244a
Km (μM)	22.1±3.42	49.3±2.41b
CLint (ml min−1 mg protein−1)	0.0142±0.00134	0.00539±0.00102b

Abbreviations: V_max, maximum velocity; K_m, Michaelis–Menten constant; CL_int, intrinsic clearance.

Data are expressed as mean±s.d. (n=5; each). Significant difference from without DA-8159,

^aP<0.05 and

^bP<0.001.