Table 1.
Physiological parameters and plasma cholesterol and triacylgylcerol of all experimental groups
| Parameter | CTRL | Ang II | Ang II +Rosi-2 | Ang II +Feno | Ang II +Rosi-2 +Feno | Rosi-2 +Feno | Ang II +Rosi-1 | Ang II +Rosi-1 +Feno | Rosi-1 +Feno |
|---|---|---|---|---|---|---|---|---|---|
| BW (g) | 251±5 | 243±8 | 228±3 | 236±6 | 231±5 | 225±10 | 232±6 | 233±5 | 239±8 |
| HW (mg) | 887±36 | 992±43 | 926±27 | 924±10 | 987±34 | 846±27 | 936±35 | 946±34 | 872±25 |
| RHW (mg g−1) (× 100) | 353±9 | 409±13a | 406±11a | 392±8a | 380±10 | 378±11 | 404±12a | 406±11a | 367±10 |
| Plasma cholesterol (M) | 1.6±0.1 | 1.6±0.1 | 1.7±0.1 | 1.2±0.1b | 1.4±0.1b | 1.2±0.1b | 1.5±0.1 | 1.3±0.1b | 1.1±0.1b |
| Plasma triglycerides (M) | 1.6±0.2 | 1.4±0.1 | 0.7±0.1c | 0.9±0.1c | 0.5±0.1c | 0.6±0.1c | 0.9±0.1c | 0.7±0.1c | 0.6±0.1c |
| Plasma glucose (M*) | 12.1±0.4 | 11.8±0.6 | 10.8±0.5 | 12.4±0.6 | 13.6±0.8 | 12.6±1.0 | 11.3±0.7 | 13.3±0.8 | 12.1±0.6 |
Abbreviations: BW, body weight; CTRL, control; Feno, fenofibrate; HW: heart Weight; RHW, relative HW.
Rosi-2 and Rosi-1, rosiglitazone 2 mg kg−1·day−1 and 1 mg kg−1 day−1, respectively.
Values are means±s.e.m.
*
Plasma glucose was measured in samples that had been snap-frozen and stored at −80°C.
a
P<0.05 vs CTRL, Rosi-2+Feno, Rosi-1+Feno.
b
P<0.01 vs Ang+Rosi-2, Ang II, CTR.
c
P<0.01 vs CTRL, Ang II; one-way ANOVA followed by Newman–Keuls test.