Table 2.
Morphological characteristics of aorta and mesenteric resistance arteries
| Parameter | CTRL | Ang II | Ang II +Rosi-2 | Ang II +Feno | Ang II+Rosi-2 +Feno | Rosi-2 +Feno | Ang II +Rosi-1 | Ang II+Rosi-1 +Feno | Rosi-1 +Feno |
|---|---|---|---|---|---|---|---|---|---|
| Aorta (histology) | |||||||||
| Lumen, (μm) (× 102) | 12.4±0.3 | 13.0±0.2 | 13.0±0.2 | 13.8±0.3 | 14.5±0.7 | 13.4±0.4 | 11.8±0.3 | 13.7±0.7 | 13.9±0.4 |
| Media, (μm) | 97.7±3.6 | 127.5±10.3a | 120.6±5.9† | 133.1±6.2† | 125.3±7.4 | 104.0±0.9 | 125.0±3.8† | 117.3±5.6 | 95.8±3.2 |
| M/L, % | 7.9±0.3 | 9.8±0.7a | 9.3±0.5a | 9.6±0.4a | 8.6±0.2 | 7.8±0.3 | 10.5±0.2b | 8.9±0.1 | 6.9±0.1 |
| MCSA, (μm2) (× 104) | 46.2±1.3 | 56.8±4.4b | 53.1±1.1b | 57.6±1.5b | 53.1±1.0b | 47.8±1.6 | 52.9±1.2b | 52.9±1.2b | 47.0±1.8 |
| Mesenteric arteries (myograph) | |||||||||
| Lumen (μm) | 234±18 | 205±13 | 254±13 | 245±24 | 250±19 | 267±15 | 236±9 | 252±13 | 249±19 |
| Media, (μm) | 19.9±0.5 | 22.5±0.8 | 23.5±1.3 | 20.5±2.3 | 24.8±1.6 | 21.0±2.2 | 22.0±1.1 | 22.7±1.0 | 17.2±2.7 |
| M/L (%) | 8.1±0.9 | 10.7±0.5a | 8.6±0.7 | 7.9±0.6 | 9.2±1.3 | 7.2±0.7 | 9.3±0.4 | 9.2±0.6 | 7.1±1.1 |
| MCSA, (μm2) (× 103) | 17.6±1.2 | 16.9±1.3 | 20.3±1.4 | 19.1±4.0 | 21.1±1.1 | 19.3±2.6 | 18.0±1.3 | 19.6±1.1 | 14.1±2.0 |
Abbreviations: CTRL, control; Feno, fenofibrate; MCSA: media cross-sectional area; M/L, media-to-lumen ratio.
Rosi-2 and Rosi-1, rosiglitazone 2 mg kg−1day−1 and 1 mg kg−1 day−1, respectively.
Values are means±s.e.m.
a
P<0.05 vs CTRL, Rosi-2+Feno and Rosi-1+Feno.
b
P<0.05 vs CTRL; two-way ANOVA followed by Newman–Keuls test.