Figure 3.
Isolated ductus arteriosus from fetal mouse. Comparison of contractile responses to ZnPP (10 μM) in WT vs HO-2- and COX-deleted preparations. Note that results with COX mutants were the same at 12.5% O2 (n=3 for each genotype). Wall tension (mN mm−1) before treatment was as follows: WT, 0.28±0.07; HO-2−/−, 0.15±0.09; COX1−/−, 0.31±0.07; COX2−/−, 0.16±0.04. For each group, the number of experiments is given above the columns, and a significant difference (P<0.01; ANOVA) between WT and HO-2−/− preparations is indicated with an asterisk.