Abstract
Ectopic production and secretion of hormones by a wide variety of tumours has been known for many years. Recently human chorionic gonadotropin (HCG) production and/or secretion have been noted in 15 cases with prostatic adenocarcinoma (Fukutani et al. 1983; Papapetrou et al. 1980: Broder et al. 1977; Menon & Stefani 1980; McManus et al. 1976) and in two with upper urinary tract transitional cell carcinoma (Fukutani et al. 1983; McManus et al. 1976). In this study we utilised the indirect immunoperoxidate technique to demonstrate beta-HCG production in prostatic adenocarcinoma and upper urinary tract urothelial tumours. Of 100 cases of prostatic adenocarcinoma beta-HCG production was demonstrated in nine cases, eight of which were poorly differentiated, and of 14 urothelial tumours of the upper urinary tract beta-HCG production was present in two high grade transitional cell carcinomas.
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- Civantos F., Rywlin A. M. Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotrophins. Cancer. 1972 Mar;29(3):789–798. doi: 10.1002/1097-0142(197203)29:3<789::aid-cncr2820290337>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
- Fukutani K., Libby J. M., Panko W. B., Scardino P. T. Human chorionic gonadotropin detected in urinary concentrates from patients with malignant tumors of the testis, prostate, bladder, ureter and kidney. J Urol. 1983 Jan;129(1):74–77. doi: 10.1016/s0022-5347(17)51926-6. [DOI] [PubMed] [Google Scholar]
- Javadpour N. The value of biologic markers in diagnosis and treatment of testicular cancer. Semin Oncol. 1979 Mar;6(1):37–47. [PubMed] [Google Scholar]
- Menon M., Stefani S. S. Evaluation of human chorionic gonadotropin-beta levels in prostatic carcinoma. Urol Int. 1980;35(4):291–293. doi: 10.1159/000280334. [DOI] [PubMed] [Google Scholar]
- Papapetrou P. D., Sakarelou N. P., Braouzi H., Fessas P. Ectopic production of human chorionic gonadotropin (hCG) by neoplasms: the value of measurements of immunoreactive hCG in the urine as a screening procedure. Cancer. 1980 May 15;45(10):2583–2592. doi: 10.1002/1097-0142(19800515)45:10<2583::aid-cncr2820451018>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
- Shah V. M., Newman J., Crocker J., Chapple C. R., Collard M. J., O'Brien J. M., Considine J. Ectopic beta-human chorionic gonadotropin production by bladder urothelial neoplasia. Arch Pathol Lab Med. 1986 Feb;110(2):107–111. [PubMed] [Google Scholar]