Figure 7.

HPLC analysis of bile pigments. Bile was collected by cannulation of the bile ducts of rats from Groups A and C, 21 days after the second virus injection. (A) A normal Wistar rat bile analysis profile where greater than 95% of the bilirubin in the bile is conjugated. (B) Bile analysis of an untreated Gunn rat in which all of the bilirubin in bile is unconjugated. (C) Bile analysis from a control rat from Group C after the second virus injection. The vast majority of the bilirubin is unconjugated. (D) Analysis of bile in a rat from Group A after the second injection showing that most of the bilirubin is conjugated. BMG, bilirubin monoglucuronide; BDG, bilirubin diglucuronide; UCB, unconjugated bilirubin.