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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Gastroenterology. 2007 Apr 20;133(1):268–277. doi: 10.1053/j.gastro.2007.04.031

Figure 7. RRV-primed hepatic CD8+T cells have tropism to the biliary epithelium.

Figure 7

Immunostaining of extrahepatic bile ducts with anti-CD3 and anti-cytokeratin antibodies shows a greater number of CD3+ cells in the subepithelial space (A) and within the epithelium (B) in mice transplanted with RRV-primed hepatic CD8+ cells. C depicts the red/pink staining in CD3+ cells and green staining in cytokeratin+ duct epithelium. C1 is from wild-type mice infected with RRV; C2 is from Rag2-/- mice transplanted with RRV-naïve hepatic CD8+ cells; and C3 and 4 are from Rag2-/- mice transplanted with RRV-primed CD8+ cells. Magnification × 6000; *denotes P<0.05 when RRV-CD4+ or RRV-CD8+ cells are compared to RRV-naïve CD8+ controls; N=4 mice per group.