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ICRF-193 disrupts pairing in clone 8 cells. Nuclei are from clone 8 cells treated with inhibitors of topoisomerase I (4 μm camptothecin) or topoisomerase II (5 μm m-amsacrine, 10 μm ICRF-193) and imaged with FISH targeting 28B1 (A) or 16E1 (B). Control nuclei are from cells treated with DMSO. Nuclei are from cultures represented in Figure 6, F and G.
