TABLE 2.
ICRF-193 disrupts pairing more effectively in the presence of a homolog
| 8C8 (%)
|
16E1 (%)
|
28B1 (%)
|
44F1 (%)
|
|||||
|---|---|---|---|---|---|---|---|---|
| Clone 8 | Kc167 | Clone 8 | Kc167 | Clone 8 | Kc167 | Clone 8 | Kc167 | |
| Control | 93 ± 2 | 73 ± 2 | 89 ± 1 | 65 ± 7 | 84 ± 4 | 84 ± 5 | 90 ± 6 | 79 ± 10 |
| ICRF-193 | 86 ± 2 | 55 ± 2 | 83 ± 1 | 32 ± 0.4 | 51 ± 5 | 52 ± 5 | 75 ± 3 | 59 ± 9 |
| Difference | 7 ± 3 | 18 ± 2 | 6 ± 1 | 33 ± 7 | 31 ± 6 | 32 ± 6 | 15 ± 7 | 20 ± 13 |
Data represent the percentage of single-signal nuclei (±SD). Ns = 149–583 (two to three trials), except in the case of Kc167 cells treated with ICRF-193 and labeled with probe targeting 16E1, where N = 93 (two trials). Underlining indicates data from FISH analyses targeting regions on the X chromosome in clone 8 cells, which carry only a single X.