TABLE 5.
Rescuing haplo-insufficiency
| Duplication | Deficiency | Deletion cytology | Deletion size | Deletion phenotype |
|---|---|---|---|---|
| Dp(2;2)EDP5 | Df(2L)ED165 | 22F4–23B81 | 379,732 | Lethal over SM6a |
| Dp(2;2)EDP5 | Df(2L)ED183 | 23A3–23C21 | 156,582 | Lethal over SM6a |
| Dp(2;2)EDP5 | Df(2L)ED184 | 23A3–23C21 | 154,547 | Lethal over SM6a |
| Dp(2;2)EDP5 | Df(2L)ED195 | 23A3–23C41 | 265,279 | Lethal over SM6 |
| Dp(2;2)EDP5 | Df(2L)ED196 | 23A3–23C41 | 263,244 | Lethal over SM6a |
| Dp(2;2)EDP5 | Df(2L)ED167 | 22F4–23B81 | 380,892 | Lethal over SM6a |
| Dp(2;2)EDP3 | Df(2L)ED209 | 23A3–23C51 | 302,629 | Lethal over SM6a |
| Dp(2;2)EDP6 | Df(2L)ED389 | 25F5–26D7 | 663,854 | Weak over SM6a |
| Dp(2;2)EDP1 | Df(2L)ED378 | 26B2–26D7 | 465,644 | Weak over SM6a |
| Dp(2;2)EDP1 | Df(2L)ED6461 | 26C1–26F3 | 379,912 | Haplo-semilethal |
| Dp(2;2)EDP26 | Df(2L)ED522 | 28D3–28E12 | 94,779 | Minute |
| Dp(2;2)EDP9 | Df(2L)ED678 | 29F5–30B12 | 623,585 | Weak over SM6a |
| Dp(2;2)EDP9 | Df(2L)ED716 | 30E1–31B13 | 333,105 | Haplo-lethal |
Chromosome 2L duplications that can rescue otherwise inviable DrosDel deletions. Duplication descriptions are from Table 4. The relevant DrosDel deletion along with its size and predicted cytology are given. The phenotype of the heterozygous deletion is described in the phenotype column. Three of these regions are known to harbor Minute loci: 23B1, 28D2, and 31A3 (S. Marygold and K. Cook, personal communication).