TABLE 3.
GOs/biological themes associated with alterations in gene expression in detrusor and corporal myocytes after 1 week of STZ-DM
| System | Gene category | List hits | EASE score |
|---|---|---|---|
| Detrusor myocytes | |||
| Up-regulation: | |||
| GO cellular component | Actin cytoskeleton | 7 | 1.16E-02 |
| GO cellular component | Myosin | 4 | 2.29E-02 |
| GO biological process | Cell proliferation | 16 | 1.48E-03 |
| GO biological process | Catabolism | 17 | 1.90E-03 |
| GO biological process | Protein catabolism | 11 | 1.17E-02 |
| GO biological process | Macromolecule catabolism | 11 | 1.38E-02 |
| GO biological process | Protein metabolism | 26 | 1.44E-02 |
| GO biological process | Glycolysis | 4 | 4.01E-02 |
| GO biological process | Monosaccharide catabolism | 4 | 4.39E-02 |
| GO biological process | Hexose catabolism | 4 | 4.39E-02 |
| GO biological process | Alcohol catabolism | 4 | 4.39E-02 |
| GO biological process | Glucose catabolism | 4 | 4.39E-02 |
| GO molecular function | Calcium ion binding | 11 | 1.61E-02 |
| GO molecular function | Peptidase activity | 10 | 2.31E-02 |
| GO molecular function | Actin binding | 6 | 2.69E-02 |
| GO molecular function | Transferase activity | 18 | 4.37E-02 |
| GO molecular function | Enzyme inhibitor activity | 6 | 4.43E-02 |
| Down-regulation: | |||
| GO biological process | Cytoskeleton organization and biogenesis | 7 | 3.44E-03 |
| GO biological process | Cell motility | 8 | 3.90E-03 |
| GO biological process | Cell organization and biogenesis | 9 | 7.03E-03 |
| GO biological process | Cytoplasm organization and biogenesis | 8 | 8.01E-03 |
| GO biological process | Muscle contraction | 5 | 1.40E-02 |
| GO biological process | Regulation of muscle contraction | 3 | 3.20E-02 |
| Corporal myocytes | |||
| Up-regulation: | |||
| GO biological process | Ion transport | 21 | 3.21E-04 |
| GO biological process | Metal ion transport | 15 | 4.62E-04 |
| GO biological process | Cation transport | 16 | 4.99E-04 |
| GO biological process | Monovalent inorganic cation transport | 12 | 3.34E-03 |
| GO biological process | Sodium ion transport | 7 | 4.87E-03 |
| GO biological process | Potassium ion transport | 7 | 4.40E-02 |
| GO biological process | Transport | 30 | 4.88E-02 |
| GO cellular component | Voltage-gated sodium channel complex | 3 | 3.30E-02 |
| GO molecular function | Ion channel activity | 12 | 3.09E-02 |
| GO molecular function | Cation channel activity | 9 | 4.09E-02 |
| GO molecular function | ATPase activity\, coupled to transmembrane movement of ions | 4 | 4.87E-02 |
| GO molecular function | ATPase activity\, coupled to transmembrane movement of ions\, phosphorylative mechanism | 4 | 4.87E-02 |
| Down-regulation: | |||
| GO cellular component | Collagen | 2 | 3.41E-02 |
| GO molecular function | Cyclin-dependent protein kinase regulator activity | 2 | 3.27E-02 |