Table 2.
Basal extracellular concentration of 5-HT in rat hippocampus after chronic treatment with 5-HT1A agonists
| Treatment (mg kg−1 per day) | 3 days fmol 20 μl−1 | 7 days fmol 20 μl−1 | 14 days fmol 20 μl−1 |
|---|---|---|---|
| Saline | 47.9±6.1 (10) | 47.7±4.7 (10) | 35.9±4.8 (10) |
| F13714 0.63 | 53.5±3.8 (5) | 48.7±5.0 (6) | 40.7±5.5 (6) |
| F13714 2.5 | 31.8±2.4 (5) | 37.3±3.9 (7) | 33.6±4.5 (6) |
| Flesinoxan 10 | 37.2±6.0 (6) | 41.7±5.0 (5) | 42.3±3.6 (6) |
5-HT1A; 5-hydroxytryptamine1a.
For each rat, basal extracellular concentration of 5-HT is the mean (fmol 20 μl−1)±s.e.m. of the four samples preceding buspirone injection. Data are mean±s.e.m. for the number of rats indicated in brackets.