Table 1.
Effect of intra-DFA microinjection of nicotine or choline on changes of MSAP, HR and both sides of CCA blood flow
| nmol | 10 | 20 | 40 | 80 | 160 |
|---|---|---|---|---|---|
| Nicotine | |||||
| MSAP (%) | 5.3±1.7 | 6.6±0.5 | 7.7±2.0 | 6.4±1.3 | 6.4±1.7 |
| HR (%) | 4.8±4.9 | 5.9±0.8 | 6.8±1.3 | 7.6±1.1 | 6.7±2.1 |
| ICCA (%) | 37±9** | 80±11**, a | 113±14**, b | 93±12** | 80±14** |
| CCCA (%) | 5±2 | 6±1 | 6±2 | 7±3 | 7±3 |
| Choline | |||||
| MSAP (%) | 3.3±0.6 | 5.6±1.6 | 6.5±2.1 | 7.3±1.8 | 6.3±1.8 |
| HR (%) | 4.8±4.9 | 4.2±0.8 | 4.8±2.2 | 6.6±3.2 | 6.5±3.1 |
| ICCA (%) | 22±5** | 31±9**, c | 54±14**, d | 108±11**, e | 108±15** |
| CCCA (%) | 4±1 | 5±2 | 5±3 | 6±2 | 6±3 |
CCA, common carotid arterial blood flow; CCCA, contralateral common carotid artery blood flow; DFA, dorsal facial area; HR, heart rate; ICCA, ipsilateral common carotid artery blood flow; MSAP, mean systemic arterial pressure.
N=5 for either nicotine or choline group. Values are mean±s.e.m.
**P<0.01 vs vehicle;
aP<0.01 vs nicotine 10 nmol;
bP<0.01 vs nicotine 20 nmol;
cP<0.05 vs choline 10 nmol;
dP<0.05 vs choline 20 nmol;
eP<0.01 vs choline 40 nmol by Student's t-test.