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. 2006 Aug 14;149(2):199–205. doi: 10.1038/sj.bjp.0706858

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Copyright 2006, Nature Publishing Group

This is an open-access article, permitting distribution and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation or the creation of derivative works without specific permission.

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Synthesis of BMSA. 1, descyano-bimakalim; 2, descyano-bimakalim-6-sulphochloride; 3, BMSA (see Materials for details). The pK_a value of benzosulphonic acid is 0.7 (Weast, 1981–1982). Assuming that this holds also for BMSA, at pH 7.4, the ratio of the charged to the neutral form is 10^7.4–0.7=5 × 10⁶.