Table 1.
Effect of the purinoceptor blocker suramin (200 μM) on relaxations to EFS (2 and 4 Hz) and NO (10 μM) in gastric fundus and circular jejunal strips and intact jejunal segments
|
Gastric fundus strips |
Jejunal segments |
Circular jejunal strips |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| EFS 2 Hz | EFS 4 Hz | NO | EFS 2 Hz | EFS 4 Hz | NO | EFS 2 Hz | EFS 4 Hz | NO | |
| Control (%) | 52±6 | 71±4 | 68±7 | 41±3 | 50±2 | 51±5 | 71±4 | 77±4 | 73±5 |
| Suramin (%) | 48±6 | 67±5 | 65±4 | 46±4 | 53±4 | 53±4 | 74±3 | 83±2 | 78±3 |
Abbreviations: EFS, electrical field stimulation; NO, Nitric oxide.
Relaxations are expressed as % relaxation of a prostaglandin F2α-induced contraction and shown as mean±s.e.m. for n=5 experiments. Student's t-test for paired observations did not show significant differences.