Table 2.
Effect of ODQ (10 μM) and NS 2028 (10 μM) on relaxations to isoprenaline (3–30 nM) in gastric fundus and circular jejunal muscle strips and in intact jejunal segments
|
Gastric fundus strips |
Jejunal segments |
Circular jejunal strips |
||||
|---|---|---|---|---|---|---|
| ISO 10 nM | ISO 30 nM | ISO 3 nM | ISO 10 nM | ISO 3 nM | ISO 10 nM | |
| Control (%) | 20±2 | 64±2 | 31±4 | 71±4 | 26±3 | 67±6 |
| ODQ (%) | 19±4 | 59±8 | 28±5 | 69±6 | 27±3 | 72±7 |
| Control (%) | 23±3 | 72±8 | 27±2 | 66±2 | 29±4 | 70±6 |
| NS 2028 (%) | 26±3 | 74±6 | 32±3 | 73±5 | 30±2 | 73±8 |
Abbreviation: ISO: isoprenaline.
Relaxations are expressed as % relaxation of a prostaglandin F2α-induced contraction and shown as mean±s.e.m. for n=4 experiments. Student's t-test for paired observations did not show significant differences.