Table 1.
Effects of glibenclamide (50 μM) on electrical properties of motoneurons
| Control | Glibenclamide | P-value | |
|---|---|---|---|
| Vrest, mV | −72±1.4 | −75±1.3 | 0.007a |
| Rin, MΩ | 21±1.8 | 25±2.4 | 0.03a |
| Overshoot, mV | 15±1.2 | 19±1.1 | 0.009a |
| Spike rise time, ms | 1.3±0.1 | 1.3±0.1 | 0.98 |
| Inflection point, mV | −47±1.6 | −46±1.5 | 0.6 |
| Time to peak, ms | 3.3±0.2 | 3.5±0.2 | 0.1 |
| Stimulus threshold, V | 0.6±0.1 | 0.6±0.1 | 0.09 |
Abbreviations: Vrest=resting membrane potential; Rin=input resistance.
Data presented are means±s.e.; n=11.
a
Statistically significant difference. Inflection point is measured at the break between the initial segment and somatodendritic spike.