Table 3.
Levels of the two endocannabinoids, AEA and 2-AG, and of PEA, in the ipsilateral paw skin from mice or rats treated with either vehicle or AA-5-HT, 5 mg kg−1, i.p., and whose paws were treated with formalin or saline, respectively
| AEA (pmol g−1) | PEA (nmol g−1) | 2-AG (nmol g−1) | |
|---|---|---|---|
| Mice | |||
| Vehicle | 176±35 | 1.3±0.2 | 4.1±0.6 |
| AA-5-HT | 171±79 | 1.0±0.1 | 4.4±0.6 |
| Vehicle+formalin | 71±24* | 0.6±0.1* | 1.5±0.01** |
| AA-5-HT+formalin | 150±27# | 1.1±0.2§ | 2.3±0.1### |
| Rats | |||
| Vehicle | 143±14 | 0.75±0.10 | 6.1±0.08 |
| AA-5-HT | 143±21 | 0.59±0.04 | 5.8±0.13 |
| Vehicle+formalin | 107±18 | 0.61±0.06 | 2.4±0.07** |
| AA-5-HT+formalin | 279±88# | 1.28±0.45 | 3.8±0.9# |
Abbreviations: AA-5-HT, N-arachidonoyl-5-hydroxytryptamine; AEA, anandamide; 2-AG, 2-arachidonoylglycerol; PEA, N-palmitoylethanolamine.
Data are means±s.e. of n=4 determinations in 4 animals per group. Means were compared by ANOVA followed by the Bonferroni's test.
*
P<0.05
**
P<0.01, vs vehicle.
#
P<0.05
###
P<0.005 vs vehicle+formalin.
§
P=0.1 vs vehicle+formalin.