Table 1.

Halogenated derivatives of MJ were cytotoxic in Molt-4 leukemic cells

Compound	IC50 (mM)
MJ	0.5±0.03
I	0.009±0.00048*
II	0.22±0.01*
III	0.23±0.03*
IV	0.29±0.0096
V	0.39±0.03

Abbreviation: MJ, methyl jsasmonate.

Molt-4 cells (at 2 × 10⁴ per well) were seeded in 96-well plates and MJ derivatives were added at concentrations of 0.001–1 mM for 24 h at 37°C. Cell viability was determined by the XTT cell proliferation assay. IC₅₀ represents the concentration of an MJ derivative that induces death in 50% of the cells (mean±s.d., n=3). P<0.05 comparing all compounds by ANOVA

^*P<0.05, comparing pairwise compounds I, II and III with MJ by the Tukey–Kramer test.