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CB1 knockout and wild-type mice exhibited a decreased performance in the active avoidance test when treated with scopolamine (0.5 mg kg−1 i.p.), whereas only wild-type mice showed an enhanced performance when treated with physostigmine (0.1 mg kg−1 i.p.). Data represent mean±s.e.m. of n=10–20 mice per experimental group. Data are expressed as an AUC.
