Table 1.
AUC, obtained on the active avoidance paradigm (conditioned changes)
| Mean±s.e.m. | F-value | P-value | ||
|---|---|---|---|---|
| Genetical approach | Wild-type | 143.35±12.60 | ||
| 11.142 | <0.001 | |||
| CB1 knockout mice | Knockout | 198.58±14.60 | ||
| Vehicle | 132.66±12.57 | |||
| Pharmacological approach | 0.03 | 137.97±11.75 | ||
| 1 | 138.28±18.33 | 0.129 | NS | |
| Rimonabant (mg kg−1) | 3 | 131.97±10.94 | ||
| 10 | 125.56±17.61 |
Abbreviations: ANOVA, analysis of variance; AUC, area under the curve; NS, non significant.
A significant increase in the performance in the active avoidance paradigm was observed in CB1 knockouts compared to wild-type mice. The performance in this paradigm was not modified by rimonabant. One-way ANOVA (genotype for the genetical approach and treatment for the pharmacological approach).