Table 1.

Effects of HDACi on bone destruction in prophylactic study in mice^a

	Radiological score	BV/TV (%)
Vehicle	3.9±0.4	1.998±0.228
SAHA (5λmg kg−1)	2.4±0.4*	2.609±0.421
SAHA (50λmg kg−1)	2.4±0.5*	1.439±0.358
MS-275 (3λmg kg−1)	0.9±0.5**	4.889±0.823**
MS-275 (10λmg kg−1)	0.0±0.0***	6.193±0.448***
MTX (100 μg kg−1)	2.7±0.4*	2.951±0.306*
Intact	0.0±0.0***	11.386±0.382***

Abbreviations: BV/TV, bone volume/tibial volume; HDAC, histone deacetylase inhibitor; MTX, methotrexate.

^aData are expressed as mean±s.e.m.

^*P<0.05

^**P<0.01

^***P<0.001, as compared with vehicle treatment (n=10) (radiological score: Wilcoxon two-sample test; BV/TV: two-tailed independent sample t-test).