Table 2.
Profile of inhibition of specific HDACs by MS-275 or SAHA
| General HDAC | HDAC1 | HDAC2 | HDAC3 | HDAC6 | |
|---|---|---|---|---|---|
| MS-275 | 0.095±0.11 | 1.04±0.13 | 0.68±0.24 | 0.12±0.09 | >50 |
| SAHA | 0.088±0.08 | 2.35±0.21 | 0.33±0.12 | 0.86±0.21 | >50 |
Abbreviations: HDAC, histone deacetylase inhibitor.
Data shown are IC50 values (μM; mean±s.e.m.) obtained from four assays.