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MS-275 and SAHA inhibit HDAC activity in extracts of spleen cells from mice treated in vivoa
| General HDAC assay | |
|---|---|
| Vehicle | 2345±63 |
| MS-275 (10 mg kg−1) | 1447±183* (38%) |
| SAHA (50 mg kg−1) | 1972±30* (16%) |
Results shown are fluorescent units of activity per 10 μg nuclear protein (means±s.e.m., from five assays). In parentheses, results are shown as % inhibition relative to the value after vehicle treatment.
P=0.05 vs vehicle; means±s.e.m., from five mice.
