Table 1.
Effect of L-NAME on heart rate, coronary flow and recovery of flow in the marmoset isolated heart
Group |
Heart rate (beats min−1) |
Coronary flow (ml min−1 g−1) I–5 min |
Recovery of flow (ml min−1 g−1) |
|||
---|---|---|---|---|---|---|
l–5 min | l–1 min | l–5 min | l–1 min | R+l min | R+5 min | |
Control | 207±67 | 231±17 | 9±1 | 11±2 | 10±2 | 8±1 |
L-NAME | 192±11 | 195±12* | 7±1 | 6±1* | 9±1 | 7±1 |
Abbreviation: L-NAME, L-NG-nitro-L-arginine methylester.
Time refers to min before (–) onset of ischaemia (l) and (+) refers to min after the onset of reperfusion (R). Values are mean±s.e.m. n=10/group.
P<0.05 vs controls. Values before introduction of L-NAME were not significantly different between groups (data not shown).