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The effects of sildenafil, tadalafil or vardenafil (all at 10−7–10−4 M), on nitrergic responses in preparations of rabbit corpus cavernosum. The tissue received EFS (5 Hz, 40 V, 0.3 ms pulse duration, 25 pulses at intervals of 2 min) and was pretreated with phenylephrine (3 × 10−6 M), scopolamine (10−5 M) and guanethidine (10−5 M). Results are shown as percentage of the duration of the relaxation response induced by EFS (means±s.e.m.).
