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. 2006 Dec 18;150(3):353–360. doi: 10.1038/sj.bjp.0706991

Table 1.

Basal release of NO/NO2− from the cavernous tissue of the rabbit penis before (control) and during addition of sildenafil, tadalafil or vardenafil (all at 10−5 and 10−4 M)

Sildenafil              
 10−5 M Control     10−4 M Control    
 8±1 7±1 n=7 NS 10±2 12±2 n=11 NS
               
Tadalafil              
 10−5 M Control     10−4 M Control    
 10±3 10±3 n=7 NS 17±4 16±3 n=7 NS
               
Vardenafil              
 10−5 M Control     10−4 M Control    
 8±1 9±1 n=7 NS 10±2 15±2 n=10 **

Abbrevations: NO, Nitric oxide; NS, not significant, PDE, phosphodiesterase.

Statistically significant change of NO/NO2−-release is denoted by **(P<0.01). Results are shown as pmol/min, mean±s.e.m. where n denotes the number of animals and tissues studied at each concentration of PDE inhibitor.