Table 2.

Antagonist activity of AGN 204396 3 × 10⁻⁵ M at human recombinant prostanoid receptor subtypes

Human prostanoid receptor	Agonist log EC50±s.d. in the presence of vehicle	Agonist log EC50±s.d. in the presence of AGN 204396 3 × 10−5 M	P Value (comparing agonist EC50 in the presence and absence of AGN 204396 at 3 × 10−5 M)
DP	PGD2: −8.676±0.097	PGD2: −8.706±0.091	0.8274 NS
EP1	PGE2: −9.074±0.094	PGE2: −9.630±0.093	0.0002**
EP2	PGE2: −8.300±0.111	PGE2: −8.493±0.110	0.2280 NS
EP3	PGE2: −9.403±0.078	PGE2: −9.580±0.116	0.2082 NS
EP4	PGE2: −9.903±0.065	PGE2: −9.979±0.061	0.4015 NS
FP	PGF2α: −8.442±0.055	PGF2α: −8.409±0.062	0.6931 NS
IP	Carbocyclin: −7.347±0.077	Carbocyclin: −7.094±0.078	0.0273*
TP	U-46619: −9.494±0.101	U-46619: −6.175±0.057	<0.0001***

Abbreviation: NS=non significant.

Values are log EC₅₀±s.d.. n=3 of experiments performed in triplicate,

^*P<0.05,

^**P<0.001,

^***P<0.0001.