Table 1.
Inflammatory cell infiltration and activation (mean values ±s.e.m., n=6 animals per group) in BAL fluid of BN rats treated with vehicle (0.5% ethanol; 0.2 ml i.t.) or capsaicin (30 μgkg−1 i.t.)
| Vehicle (0.5% ethanol) 0.2 ml i.t. (n=6) | Capsaicin 30 μgkg−1 i.t. (n=6) | |
|---|---|---|
| Neutrophils × 106 | 0.18±0.03 | 0.29±0.02* |
| MPO (mU ml−1) | 52.1±10.0 | 94.9±10.3* |
| Eosinophils × 106 | 0.93±0.24 | 1.09±0.05 |
| EPO (mU ml−1) | 2.0±0.2 | 2.2±0.3 |
| Protein (μg ml−1) | 0.21±0.03 | 0.26±0.03 |
| Macrophages (× 106) | 1.99±0.25 | 4.14±0.33** |
| Lymphocytes (× 106) | 0.39±0.10 | 0.44±0.05 |
| Total cells (× 106) | 3.60±0.44 | 5.96±0.40** |
Abbreviations: BN, Brown Norway; EPO, eosinophil peroxidase; MPO, myeloperoxidase.
Animals were killed 60 min after challenge with either substance. The significance levels *P<0.05, and **0.001<P<0.01 refer to comparisons between vehicle- and capsaicin-treated animals.