Table 2.

Inflammatory cell infiltration and activation (mean values±s.e.m.) in BAL fluid of BN rats treated with (i) capsazepine (3.5 mgkg⁻¹ i.t.; n=5) or its vehicle (0.2 ml of a 0.5% ethanol solution i.t.; n=4); (ii) DSCG (10 mgkg⁻¹ i.t., n=5) or its vehicle (0.1 ml saline i.t., n=5); or (iii) DNK333 (10 mgkg⁻¹ i.p., n=5) or its vehicle (2 mgkg⁻¹ of a 4% DMSO solution in Neoral placebo, n=5). Capsaicin was administered 30 min after treatment with capsazepine, DNK333 or their respective vehicles, and immediately following administration of DSCG or its vehicle

	Vehicle (0.5% ethanol)	Capsazepine (3.5  mg kg−1 i.t.)	Vehicle (4% DMSO in Neoral placebo)	DNK333 (10  mg kg−1 i.p.)	Vehicle saline 0.2 ml i.t.	DSCG (10  mg kg−1 i.t.)
Neutrophils (× 106)	0.49±1.58	0.37±0.09	0.25±0.04	0.25±0.04	0.49±1.58	0.17±0.03
MPO mU mL−1	46±3	35±8	43±5	40±2	46.8±4	41±1
Eosinophils (× 106)	1.22±0.32	0.80±0.1*	0.94±0.31	0.83±0.39	1.17±0.12	0.92±0.16
Macrophages (× 106)	5.10±0.76	4.60±0.49	3.73±0.64	3.03±0.69	4.77±0.82	5.62±0.48
Lymphocytes (× 106)	1.30±0.56	0.83±0.06	0.68±0.30	0.26±0.06	1.28±0.37	0.28±0.05*
Total cells (× 106)	8.10±1.66	6.10±0.63	5.81±0.91	4.37±1.12	7.70±1.39	6.98±0.48

Abbreviations: BAL, bronchoalveolar lavage; DMSO, dimethyl sulfoxide; DSCG, di-sodium cromoglycate; MPO, myeloperoxidase.

Animals were killed 60 min after capsaicin administration for BAL fluid analysis. Substances were administered i.t., with the exception of DNK-33 and its vehicle, which were applied i.p. The significance levels ^*P< 0.05 refer to comparisons between vehicle-treated and capsazepine or DSCG-treated animals.