Table 4.

Effects of benzodiazepine site ligands of differing intrinsic efficacies on GABA-mediated modulation of [³⁵S]TBPS binding in rat and human postmortem cortex and cerebellum membranes

	IC50, μM
	Human		Rat
	Cortex	Cerebellum	Cortex	Cerebellum
Control	0.90±0.07	0.65±0.11	1.13±0.15	0.90±0.08
Diazepam	0.43±0.04*	0.33±0.10*	0.56±0.03*	0.48±0.03*
Ro15-1788	0.74±0.05	0.65±0.06	1.05±0.01	0.88±0.08
DMCM	2.29±0.38*	1.42±0.31*	1.91±0.04*	2.54±0.11*

Abbreviations: ANOVA, analysis of variance; DMCM, methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate; GABA, γ-aminobutyric acid; [³⁵S]TBPS, [³⁵S]t-butylbicyclophosphorothionate.

Data shown are mean±s.e.m. (n=3–4). Statistical differences between groups were evaluated using a one-way ANOVA with post hoc Dunnett's multiple comparison tests for each radioligand. (^*P<0.05).