Table 2.

Summary of pharmacological activity of F15063 in models predictive of activity against positive symptoms of schizophrenia

Species	Model	Route	Response	Parameter	Dose (mg kg−1)
Rat	Methylphenidate-induced behaviours	i.p.	Blocks gnawing	ED50	0.24 (0.14–0.41)
			Normalizes behaviour	ED50	1.10 (0.70–1.80)
		p.o.	Blocks gnawing	ED50	0.93 (0.66–1.30)
			Normalizes behaviour	ED50	2.50 (1.00–6.20)
	Amphetamine hyperlocomotion	i.p.	Blocks hyperlocomotion	ED50	0.23 (0.15–0.31)
		p.o.	Blocks hyperlocomotion	ED50	1.66 (0.56–4.93)
	Ketamine hyperlocomotion	i.p.	Blocks hyperlocomotion	ED50	0.96 (0.28–3.30)
	Conditioned avoidance	i.p.	Blocks behaviour	ED50	0.33 (0.19–0.55)
	Apomorphine-induced PPI deficit	i.p.	Attenuates deficit	MED	0.16
Mouse	Apomorphine stereotypies	i.p.	Blocks climbing	ED50	0.30 (0.14–0.63)
			Blocks sniffing	ED50	0.37 (0.18–0.75)

Abbreviations: ED₅₀, dose (mg kg⁻¹) producing a significant difference from control in 50% of the animals tested; i.p., intraperitoneal; MED, minimal effective dose; p.o., per os.

Confidence intervals are given in parentheses.