Table 3.

Summary of pharmacological activity of F15063 in models predictive of side effects relevant to antipsychotic treatment

Symptoms	Species	Model	Route	Response	Parameter	Dose (mg kg−1)
EPS	Rat	Catalepsy	i.p.	Absence of catalepsy	ED50	>40
			p.o.	Absence of catalepsy	ED50	>40
		Catalepsy after 4 day treatment	p.o.	Absence of catalepsy		40/day
	Mouse	Catalepsy	i.p.	Absence of catalepsy	ED50	>40
Serotonin syndrome	Rat	Characteristic behaviours	p.o.	All signs	ED50	>40
			i.p.	Lower lip retraction	ED50	7 (2–30)
				Flat body posture	ED50	32 (10–102)
				Forepaw treading	ED50	>40

Abbreviations: ED₅₀, dose producing a significant difference from control in 50% of the animals tested; i.p., intraperitoneal; p.o., per os.

Confidence intervals are given in parentheses.