Table 2.

Summary of pharmacological activity of F15063 in models predictive of activity against negative symptoms and cognitive deficits of schizophrenia

Model	Response	Active dose(s) (mg kg−1 i.p.)
PCP-induced social interaction impairment	Augments interaction	0.04–0.16 & 0.63
PCP-induced impairment in reversal learning task	Ameliorates correct choice	0.16
	Diminishes latency times to respond	0.04 & 0.16
Scopolamine-induced social recognition deficit	Blocks amnesia	0.04–0.63