Figure 4.

Contralateral delivery of WIN 55,212–2. Paw withdrawal responses (PWR) to mechanical and cooling stimuli at 2, 4 and 6 days after PNL injury measured from the injured hind limb during perineural mini-osmotic pump delivery of WIN 55,212–2 (1.4 and 2.8 μg μl⁻¹ h⁻¹) or vehicle solution to the uninjured side (n=3 per group). (a) Mean paw withdrawal response force for mechanical stimulation in each treatment group. P>0.05 contralateral WIN 55,212–2 (1.4 μg μl⁻¹h⁻¹)-treated rats versus contralateral vehicle-treated rats; Kruskal-Wallis ANOVA, Dunn's test. Contralateral WIN 55,212–2 (2.8 μg μl⁻¹ h⁻¹)-treated rats versus contralateral vehicle-treated rats, ANOVA, Tukey test. (b) Mean percentage paw withdrawal response to cooling stimulation in each treatment group. P>0.05 contralateral WIN 55,212–2 (1.4 μg μl⁻¹ h⁻¹)-treated rats versus contralateral vehicle-treated rats; ANOVA, Student–Newman–Keuls. P>0.05 contralateral WIN 55,212–2 (2.8 μg μl⁻¹ h⁻¹)-treated rats versus contralateral vehicle-treated rats; ANOVA, Student–Newman–Keuls.