Table 2.

Effect of alendronate on macroscopic parameters and AP activity in rat TNBS colitis

	Colonic weight/length ratio (mg/cm)	Extension of necrosis (cm)	Damage score	Body weight gain after 5 days	AP activity (mU/mg protein)
Uninflamed	53.8±1.8	0	0	+2.3±1.6	71.1±4.8
TNBS	201.0±11.9+	3.2±0.5+	11.0±0.5+	−10.8±2.3+	169.6±36.7+
Alendronate	180.0±22.9+	3.1±0.6+	7.4±1.1+*	−5.3±3.9+*	171.1±43.0+
Sulphasalazine	143.7±41.5+	2.2±0.9+	8.1±6.5+	−12.8±2.0+	110.24±35.8+*

Abbreviations: AP, alkaline phosphatase; TNBS, trinitrobenzenesulfonic acid

The doses of alendronate and sulphasalazine were 25 and 500 mg kg⁻¹ day⁻¹, respectively. Values are means±s.e.m., n=7.

⁺Different from Control group, P<0.05

^*different from TNBS group, P<0.05.

Body weight gain is expressed as percentage change from the start of the experiment.