Table 3.
Effect of Fosamax (containing alendronate) on macroscopic parameters in rat TNBS colitis
| Colonic weight/length ratio (mg cm−1) | Diarrhea score | Extension of necrosis (cm) | Damage score | Body weight gain after 5 days | |
|---|---|---|---|---|---|
| Uninflamed | 65.4±2.2 | 0 | 0 | 0 | 4.9±0.5 |
| TNBS | 155.0±14.2+ | 2.0±0.4+ | 3.5±0.4+ | 9.4±0.7+ | −7.2±1.5+ |
| Alendronate | 125.4±15.6+* | 1.4±0.3+ | 2.1±0.7+* | 5.5±1.2+* | −12.0±1.9+* |
| Sulphasalazine | 141.5±5.7+ | 1.7±0.2+ | 3.5±0.5+ | 8.8±0.4+ | −11.6±0.8+* |
Abbreviations: TNBS, trinitrobenzenesulfonic acid.
The doses of Fosamax (containing alendronate) and sulphasalazine were 75 and 500 mg kg−1 day−1, respectively. Values are means±s.e.m., n=7.
+
Different from Control group, P<0.05.
*
Different from TNBS group, P<0.05.
Body weight gain is expressed as percentage change from the start of the experiment.