Table 4.
Affinities of F15063 at native brain monoamine sites
| Receptor | pKi±s.e.m. | Ki (95% CI) | Ki ratio vs rD2 |
|---|---|---|---|
| rD2 | 9.38±0.05 | 0.42 (0.26–0.66) | 1 |
| rD1 | 5.89±0.03 | 1284 (950–1738) | 3057 |
| r5-HT1A (cortex) | 8.24±0.07 | 5.9 (3.0–11.2) | 14 |
| r5-HT1A (hippocampus) | 8.65±0.09 | 2.3 (1.0–5.3) | 5 |
| r5-HT1B | 6.31±0.10 | 487 (180–1315) | 1159 |
| r5-HT2A | 6.57±0.01 | 270 (237–306) | 643 |
| p5-HT2C | 6.50±0.17 | 318 (57–1781) | 757 |
| rα1 | 7.29±0.01 | 51 (46–56) | 121 |
| rα2 | 6.52±0.02 | 303 (255–360) | 721 |
| rSERT | 5.98±0.03 | 1045 (776–1406) | 2488 |
Abbreviation: CI, confidence interval.
Affinity values were calculated from competition binding experiments and derived pKi values are shown±s.e.m. The corresponding geometric mean of Ki values (in nanomolar) are shown with their 95% confidence intervals.