Table 5.
Affinities of F15063 at recombinant human monoamine receptors
| Receptor | pKi±s.e.m. | Ki (95% CI) | Ki ratio vs rD2 |
|---|---|---|---|
| hD2L | 9.44±0.01 | 0.36 (0.32–0.42) | 1 |
| hD2S | 9.25±0.01 | 0.56 (0.55–0.58) | 1.6 |
| hD3 | 8.95±0.05 | 1.12 (0.68–1.58) | 3.1 |
| hD4.4 | 8.81±0.08 | 1.53 (0.68–3.48) | 4.3 |
| hD1 | 6.51±0.16 | 312 (67–1454) | 867 |
| h5-HT1A | 8.37±0.02 | 4.23 (3.36–5.34) | 12 |
| h5-HT1B | 7.04±0.05 | 91 (56–145) | 253 |
| h5-HT1D | 7.89±0.05 | 13 (7.5–21) | 36 |
| h5-HT2A | 7.77±0.08 | 17 (7–38) | 47 |
| h5-HT2B | 7.71±0.05 | 19 (12–32) | 53 |
| h5-HT2C | 7.27±0.08 | 53 (24–118) | 147 |
| h5-HT7A | 6.60±0.08 | 237 (140–400) | 658 |
| hα2A | 6.81±0.02 | 156 (136–179) | 433 |
| hα2B | 7.02±0.04 | 96 (65–141) | 266 |
| hα2C | 7.20±0.06 | 60 (33–108) | 166 |
Abbreviations: CI, confidence interval.
Affinity values were calculated from competition binding experiments and derived pKi values are shown±s.e.m. The corresponding geometric mean of Ki values (in nanomolar) are shown with their 95% confidence intervals.