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. 2007 Mar 12;151(2):278–284. doi: 10.1038/sj.bjp.0707216

Figure 5.

Figure 5

(a) The effect of the ETB receptor antagonist BQ788 (5–500 μg kg−1 i.p.) on scratching induced by ET-1 (3 ng; n=7–11). Control responses to ET-1 (open column) did not differ significantly from those observed following increasing doses of antagonist (shaded columns; P>0.05; Kruskal–Wallis test with Dunn's post hoc test versus control). (b) The ETB receptor antagonist, BQ788 (5–500 μg kg−1 i.p.), antagonized scratching induced by the ETB agonist IRL1620 10 μg (n=8). Responses were significantly reduced by the two highest doses of the antagonist (shaded columns), in comparison with scratching in the pre-antagonist control (open column; *P<0.01; Kruskal–Wallis test with Dunn's post hoc test versus control).