Figure 2.

The effect of EGb-761 (Gb) or vehicle administered 3 h post-carrageenan on mechanical allodynia. (a) The mean mechanical threshold (in force/g) measured in the ipsilateral hindpaw in adult male rats (n=7–10). Responses were measured before, 2, 4, 6 and 24 h post-carrageenan. Arrow represents time of Gb administration. (b) The effect of all doses of EGb-761 (3, 10, 30 and 300 mg kg⁻¹), diclofenac (5 mg kg⁻¹) or vehicle on mechanical allodynia in both hindpaws. Maximum change in mechanical response threshold in the ipsilateral (ipsi) and contralateral (contra) paw post-carrageenan is represented as mean % change (E_max %) from the pre-carrageenan/baseline response thresholds. EGb-761 had no effect on carrageenan-induced allodynia. Significant attenuation of allodynia by diclofencac; ^***P<0.001 vs vehicle.